The current infestation of mountain pine beetle (Dendroctonus ponderosae) is having a significant effect on the lodgepole pine forests of Interior British Columbia. By 2004, 7 million hectares had been affected by mountain pine beetle. The impact of this infestation is unprecedented in the last 100 years due to large areas of susceptible pine as a result of aggressive wildfire control activities; warmer, drier summers; and milder winters. In past infestations, a majority of the beetle-killed stands were salvaged and the cutovers were planted or left for natural regeneration. During the current outbreak, it may not be possible to salvage all the beetle-killed trees for reasons of accessibility, location, management objectives, lack of milling capacity, economic factors or other resource values, and some of the beetle-killed stands will be left. A portion of these stands will regenerate naturally over time as part of a natural disturbance pattern with fires and stand succession, but other stands will need assistance to restore them before regeneration is established. This report provides a summary of a literature review examining regeneration issues in lodgepole pine stands killed by mountain pine beetle. It also looks at regeneration following other large-scale natural disturbances, e.g., wildfire and volcanic eruptions.