Boreal caribou (Woodland Caribou, boreal population; Rangifer tarandus caribou) is a prominent mammal at the heart of a decades-long conflict between a growing resource sector and the associated risks to biodiversity. We employed the ISO 31010 Bow-tie Risk Assessment Tool (BRAT) to evaluate the cumulative effects of anthropogenic and natural factors that may affect risks to self-sustainability in boreal caribou herds of Northeastern British Columbia. We used the BRAT to produce a visual synthesis of the cumulative effects causing the growth rate of boreal caribou herds to persistently fall below a level corresponding to a 60% chance of self-sustainability (λ < 1.025). The BRAT diagram provided the basis for a quantitative Layers of Protection Analysis (LOPA) of risk probabilities for three caribou herds. We combined threat assessments from the Species at Risk Act recovery strategy (Environment Canada, 2012) with data from published landscape experiments (e.g., restoration of seismic traces, maternal penning, and wolf culls) to parameterize the LOPA in three study areas. We report the implications of a combination of mitigation options vs. current risk conditions, as well as the implications of uncertainty in threat prevention. Our analysis indicates that a combination of mitigation scenarios will best facilitate caribou herd recovery, that barriers preventing predation threats could also aid in recovery success, and that compensatory predation may account for a significant proportion of both adult and juvenile female mortality across different herds. We estimated the minimum annual cost for effective mitigation and recovery to be $CDN 224K within any of the study areas. Bow-tie diagrams are a flexible and quantifiable tool that can translate resource management solutions to the diverse audience involved in conservation decision-making: scientists, land managers, policy makers, and concerned stakeholders.