In summer 2016, more than 50 Arctic Barren Ground caribous were found dead on Prince Charles Island (Nunavut, Canada), a species recently classified as threatened. Neither predator nor sign of diseases was observed and reported. The main hypothesis is that caribous were not able to access food due to a very dense snow surface, created by a strong storm system in spring. Using satellite microwave data, a significant increase in brightness temperature polarization ratio at 19 and 37 GHz was observed in spring 2016 (60% higher than previous two winter seasons). Based on microwave radiative transfer simulations, such anomaly can be explained with a very dense snow surface. This is consistent with the succession of storms and strong winds highlighted in ERA-Interim over Prince Charles Island in spring 2016. Using several sources of data, this study shows that changes in snow conditions explain the caribou die-off due to restricted foraging.